Joe Palooka goes blind during a fight. An operation restores his vision, but he's told not to fight for a year. His trainer Knobby has picked up another fighter, but gangsters are pressing him to fix fights. Joe decides to risk his eyesight to save Knobby's honor.

Joe heads for South America to fight the Latin champ. Shipboard, he helps federal agents fight counterfeiters. He also spars with love interest Anne Howe.

The third of the Monogram series based on Ham Fisher's "Joe Palooka" comic strip, opens with Knobby Walsh, the manager of Joe Palooka trying to talk his way out of a traffic citation, and the story leading to that point is told in flashback as narrated by Walsh. Heavyweight champion Joe, after knocking out an opponent who later died in his dressing room, feels responsible and threatens to give up boxing. But the dead fighter's fiance thinks he died as the result of a drug that was given to him by a gang of gamblers, who made a rich haul betting on Palooka. Joe, Knobby and the police unite to run down the gamblers, but not before Joe also is nearly murdered by the same means...a poisoned mouthpiece. Elyse Knox is along as Joe's sweetheart Anne Howe, although Anne and Joe had long been married in the comic strip.

After losing heavyweight contender Al Costa to mob boss Florini fight promoter Knobby Walsh recruits small town boy Joe Palooka to take his place. First in the series.

In the second film of Monogram's Joe Palooka series, Joe is 'used', by two state senators scheming to obtain oil-rich lands, in a publicity campaign to get the land transferred to the state, supposedly for a park. When Joe learns that he has been used as a dupe he becomes disillusioned and leaves the prize=fighting profession. But, his manager, sparring partners, and fiancée manage to expose the land-grab scheme, clear Joe's name and discredit the crooked politicians.

An evil corporation tries to pressure a bunch of Arkansas farmers and ranchers to sell their land so they can strip-mine it for coal. The fiercely proud and stubborn Hunter family refuse to give in. This leads to a bitter conflict that results in several casualties. Eventually the take-charge no-nonsense Tom Hunter exacts a harsh revenge on the villains with the help of his bow and arrow.

Ann Fenwick is a witness to a bank robbery in the U.S. and the bandits, led by Trigger (Warner Richmond) and Leon (Ted Adams) capture her and when she disappears, a warrant is issued for her arrest as a material witness. The bank robbers flee across the border into Canda where they steal a trailer in which they lock Ann and the loot. The hitch breaks and the trailer plunges into a lake. Sergeant Renfrew (James Newill) and Constable Kelly (Dave O'Brien), of the Canadian Mounties,rescue Ann and she tells them she is a hitch-hiking tourist and gives a false name. Renfrew sends Kelly for aid, Ann escapes and Kelly returns with the news that she is wanted. The leader of the gang, Cardigan (Milburn Stone), sends the gang back for Ann and the loot, which Ann has hidden in a trappers cabin, just before Trigger recaptures her. Renfrew goes to her rescue, but is also captured. But reliable Constable Kelly is somewhere in the woods.

Muscles Tanner, a boxer, gives up the ring after two fatalities and emigrates to Canada and gets involved with two crooked lumbermen trying to evict a landowner from his plot.

Joe Palooka encounters gangsters and tries to alert the law.

Joe is scheduled for the big fight as usual. This one has more fight sequences than plot.